Application value of combined detection of coagulation and inflammatory indicators in patients with ischemic stroke
Chen Guanfeng
Long Huajing
Yu Shaomei
Wang Xiuyin
Zeng Bohuang
Abstract：Objective To investigate the clinical application value of coagulation and inflammatory indicators in patients with ischemic stroke(IS).Methods The 60 patients with IS admitted to the Stroke Center of the Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University through the emergency green channel from May 2022 to July 2023 and 55 healthy physical examiners during the same period were selected as reasearch objects and included into IS group and control group,respectively.The coagulation indicators[D-dimer and D-dimer to fibrinogen ratio(DFR)]and blood routine inflammation indicators[neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)]of all research objects were detected,and the differences of the levels of above indicators between the two groups were compared.The receiver operator characteristic(ROC)curve was drawn,the area under ROC curve(AUC)was calculated,and the diagnostic value of individual and combined detection of each indicator for IS was analyzed.Results The levels of D-dimer,DFR,NLR and PLR in IS group were significantly higher than those in control group[D-dimer(mg/L):0.34(0.19,0.73)vs.0.23(0.15,0.32);DFR:0.102(0.063,0.259)vs.0.078(0.048,0.101);NLR:6.52±6.64 vs.1.81±0.61;PLR:180.54±122.86 vs.116.33±33.25;all P＜0.05].The AUC of D-dimer,DFR,NLR,PLR detected alone and in combination for diagnosing IS were 0.698,0.657,0.868,0.673 and 0.942,respectively.Among them,the AUC used in combination was the highest,with high sensitivity and specificity,reaching 90.0%and 89.1%,respectively.Conclusions The levels of D-dimer,DFR,NLR and PLR were significantly increased in patients with IS.Compared with single indicators,the combined detection of D-dimer,DFR,NLR and PLR has the greatest diagnostic value and may be used as a marker for early auxiliary diagnosis of patients with IS.
Keywords：Ischemic strokeD-dimer to fibrinogen ratioNeutrophil to lymphocyte ratio
Publication Date：2024-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 15-18 )