Application of respiratory syncytial virus antibody detection for early infection diagnosis
Hu Shaohong
Abstract：Objective To analyze the application of respiratory syncytial virus(RSV)antibodies detection for early infection diagnosis.Methods A total of 650 suspected RSV infected individuals from January 2020 to January 2023 admitted in Pingyi County People's Hospital were selected as research objects.RSV was diagnosed by indirect fluorescence immunoassay,and a four-fold increase in serum titer of RSV-immunoglobulin G(IgG)was used to determine RSV infection in patients during the acute phase(fever,dyspnea,cyanosis,lasting several days to several weeks)and the recovery phase(remission of symptoms,resolution of inflammation,lasting several weeks to several months).Results Among the 650 patients,252 cases were tested for RSV-antigen(RSV-Ag),with 49 cases being positive,with a positive rate of 19.44%.The 398 cases were tested for RSV-immunoglobulin A(IgA),with 85 cases being positive,with a positive rate of 21.36%.The results of four-fold increase in serum titer of RSV-IgG in acute stage and convalescent stage were compared,41 cases were RSV-Ag positive,with a coincidence rate of 83.67%.The 69 cases were positive for RSV-IgA,with a coincidence rate of 84.18%.Conclusions The detection of RSV has a high coincidence rate with early RSV infection.The results of indirect fluorescence immunoassay are accurate and reliable,and the simultaneous detection of RSV-Ag and RSV-IgA could improve the early diagnostic rate of RSV infection.
Keywords：Respiratory syncytial virusInfectionPositive rate
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 397-400 )