Expression level and application value of oxidative stress markers in patients with benign prostatic hyperplasia

Zhao Qi; Yang Lei; Wang Bo

doi:10.3969/j.issn.1674-7151.2023.04.014

Abstract：Objective To investigate the expression levels and application value of oxidative stress markers in patients with benign prostatic hyperplasia.Methods The 120 patients with benign prostatic hyperplasia admitted in Ordos Dongsheng District People's Hospital from July 2019 to July 2022 were selected as research objects and included in study group,and 120 health examinees in the hospital during the same period were selected as control group.The levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and glutathione reductase(GR)expression between study group and control group,as well as patients with different degrees of disease severity were compared.The correlation between the severity of prostate hyperplasia and levels of SOD,GSH-Px and GR was analyzed.The diagnostic efficacies of SOD,GSH-Px and GR alone and in combination for benign prostatic hyperplasia was compared.Results The levels of SOD and GSH-Px in study group were lower than those in control group[SOD(μmol/L):68.67±1.27 vs.99.13±1.93,GSH-Px(mmol/L):24.17±1.52 vs.32.84±1.92,both P<0.05],GR level was higher than in control group(U/L:98.47±1.41 vs.33.49±1.46,P<0.05);The levels of SOD and GSH-Px in patients with grade Ⅲ-Ⅳ prostate enlargement were lower than those in patients with grade Ⅰ-Ⅱ prostate enlargement[SOD(μmol/L):65.56±3.72 vs.72.33±2.83,GSH-Px(mmol/L):19.62±3.82 vs.29.54±2.85,both P<0.05],GR level was higher than that in patients with grade Ⅰ-Ⅱ(U/L:143.52±3.94 vs.45.22±3.31,P<0.05).Correlation analysis showed that the severity of prostate hyperplasia was negatively correlated with SOD and GSH-Px levels,and positively correlated with GR level.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of combined detection of SOD,GSH-Px and GR in diagnosing benign prostatic hyperplasia were 97.50%,99.17%,99.14%,95.97%and 99.14%,which were higher than those of single indicator diagnosis.The receiver operator characteristic(ROC)curve showed that the area under ROC curve(AUC)of combined detection for diagnosing benign prostatic hyperplasia was higher than that of single indicator detection.Conclusion The expression levels of SOD,GSH-Px and GR in prostatic hyperplasia were significantly correlated with disease severity,which could be used as an important basis for clinical diagnosis.