Application value of combined detection of inflammation indexes and serum amyloid A in children with acute respiratory infection

Li Chuanli

doi:10.3969/j.issn.1674-7151.2023.04.011

Abstract：Objective To investigate the application value of combined detection of inflammation indexes and serum amyloid A(SAA)in children with acute respiratory infection.Methods A total of 120 children with acute respiratory infection who were admitted in Shandong Yiyang Health Group Zibo Hospital from July 2021 to July 2022 were included in observation group,and 120 uninfected children admitted during the same period were selected as control group.Using a fully automated chemiluminescence analyzer,the serum levels of procalcitonin(PCT),SAA and interleukin-6(IL-6)in two groups of children were detected using electrochemical luminescence quantitative method,and the level of C-reactive protein(CRP)was detected using rate scattering turbidimetry.Using a cell analyzer and matching reagents,the level of white blood cell count(WBC)was detected.The positive rates of PCT and CRP between the two groups were analyzed and compared.Results The levels of serum PCT,IL-6,SAA,CRP and WBC in the observation group were significantly higher than those in the control group[PCT(μg/L):4.33±1.39 vs.1.78±1.42,IL-6(ng/L):111.23±20.36 vs.37.65±10.25,SAA(mg/L):163.58±5.56 vs.9.63±1.58,CRP(mg/L):77.58±10.20 vs.67.02±9.52,WBC(×109/L):14.20±2.58 vs.7.36±1.85,all P<0.05].The positive rates of PCT and CRP in observation group were significantly higher than those in control group(PCT:35.00%vs.21.67%,CRP:84.17%vs.71.67%,both P<0.05).Conclusion Strengthening the combined detection of PCT,IL-6,SAA,CRP and WBC is helpful to understand the development of acute respiratory infection in children,so as to guide the treatment of the disease,and has high clinical value.