Preparation and characterization of medical magnetic nanoparticles containing iron oxide

Xue Wenyu; Wang Lan

doi:10.3969/j.issn.1674-7151.2023.04.008

Abstract：Objective To study the preparation method and condition of medical magnetic nanoparticles containing iron oxide,and provide reference for their better application in the field of biomedical research.Methods The preparation conditions of iron oxide nanoparticles were screened by controlling the concentration of iron salts,ammonia solution and reaction temperature.The mixed solutions of iron salts with different concentration(0.25,0.20 and 0.15 mol/L)and ammonia solutions with different concentration(2.0,1.5 and 1.0 mol/L)were prepared.Under other unchanged conditions,the reaction temperature(30,40 and 50℃)was controlled and the particle size and magnetism of iron oxide nanoparticles prepared under different conditions were detected.Results The results of single factor experiment showed that when preparing iron oxide nanoparticles using co-precipitation method,the average particle size was the highest[(20.6±0.2)nm]at 0.25 mol/L of iron salt solution,and the magnetic attraction distance was the longest[(4.06±0.19)cm].When the concentration of mixed iron salt solution was controlled to 0.25 mol/L and other conditions remained unchanged,and the ammonia concentration was 1.0 mol/L,the prepared particle magnet had the longest attraction distance[(4.06±0.20)cm].Under other optimal conditions,as the reaction temperature continued to increase,the magnetic properties of particles decreased,and the optimal reaction temperature was 30℃.Conclusion The optimal scheme for preparing iron oxide magnetic nanoparticles using co-precipitation method is 0.20 mol/L iron salt solution and 1.0 mol/L ammonia solution at 30℃.