Correlation on changes of serum indexes levels with degree of coronary artery stenosis in patients with coronary heart disease

Shen Hong

doi:10.3969/j.issn.1674-7151.2023.04.005

Abstract：Objective To investigate the correlation between changes of serum homocysteine(Hcy),C-reactive protein(CRP)and myocardial enzymes and the degree of coronary stenosis in patients with coronary heart disease(CHD).Methods The 75 patients with CHD admitted to Jinhu County People's Hospital from January 2019 to January 2022 were selected as observation group.According to the degree of coronary artery stenosis,they were divided into coronary artery stenosis>75%group(40 cases)and coronary artery stenosis≤75%group(35 cases).Other 75 healthy examinees in the hospital during the same period were included in control group.Serum samples of all subjects were collected,and Hcy was detected using enzyme cycle assay,CRP was detected using latex enhanced immunoassay,creatine kinase isoenzyme(CK-MB)was detected using immunosuppressive assay,creatine kinase(CK)was detected using phosphocreatine substrate assay,and lactate dehydrogenase(LDH)and aspartate aminotransferase(AST)were detected using International Federation of Clinical Chemistry(IFCC)method.The differences of the above indicators between observation group and control group,as well as patients with different degrees of CHD stenosis were compared.The correlation between serum indicators and the degree of coronary artery stenosis was analyzed using Pearson correlation analysis method.The receiver operator characteristic(ROC)curve was drawn and the area under ROC curve(AUC)was calculated to analyze the predictive value of above indicators for the degree of coronary artery stenosis.Results The levels of Hcy,CRP,CK-MB,CK,LDH and AST in observation group were higher than those in control group[Hcy(μmol/L):20.14±2.34 vs.8.38±1.12,CRP(mg/L):9.52±1.15 vs.3.38±0.45,CK-MB(U/L):45.63±4.32 vs.14.25±2.04,CK(U/L):230.41±12.54 vs.151.14±10.36,LDH(U/L):208.96±11.58 vs.121.41±8.96,AST(U/L):75.56±6.82 vs.36.52±4.23,all P<0.05].The levels of Hcy,CRP,CK-MB,CK,LDH and AST in coronary stenosis>75%group were higher than those in coronary stenosis≤75%group[Hcy(μmol/L):25.02±3.74 vs.16.14±2.25,CRP(mg/L):12.35±2.01 vs.7.52±1.13,CK-MB(U/L):57.59±5.52 vs.36.41±4.19,CK(U/L):255.69±15.14 vs.202.14±10.79,LDH(U/L):238.69±13.48 vs.182.14±10.13,AST(U/L):90.41±7.89 vs.68.41±6.15,all P<0.05].Serum Hcy,CRP,CK-MB,CK,LDH and AST levels were positively correlated with Gensini score(r values were 0.605,0.449,0.519,0.467,0.419,0.475,P values were all 0.000).ROC curve analysis showed that the AUC of combined detection of Hcy,CRP,CK-MB,CK,LDH and AST for predicting the degree of coronary artery stenosis was 0.962,which was higher than that of each index alone.Conclusion The levels of serum Hcy,CRP and myocardial enzymes are directly proportional to the degree of coronary artery stenosis.Early detection of these indicators could predict the degree of coronary artery stenosis and provide guidance for the development of clinical treatment plans.