Relationship between serum paraoxonase 1 and coronary artery Gensini score in patients with ischemic heart disease

Yang Jifang; Bi Tianxiong; Yao Ruinan; Huang Benlin

doi:10.3969/j.issn.1674-7151.2023.04.004

Abstract：Objective To investigate the relationship between serum paraoxonase 1(PON-1)and coronary artery Gensini score in patients with ischemic heart disease(IHD).Methods The 334 patients with IHD admitted to the First People's Hospital of Dali from January to November,2019 were selected as research objects,and 312 physical examiners in the same period were selected as control group.The activity of serum PON-1 was detected by automatic biochemical instrument.Pearson linear correlation analysis was used to analyze the correlation between PON-1 activity and coronary artery stenosis Gensini score.According to Gensini scores,IHD patients were divided into mild stenosis group(Gensini score≤60;254 cases)and severe stenosis group(Gensini score>60;80 cases).The receiver operater characteristic(ROC)curve was drawn,the area under ROC curve(AUC)was calculated,and the diagnostic efficiency of PON-1 for screening severe IHD was analyzed.Results The serum PON-1 activity of patients with IHD was lower than that in control group[U/L:115.25(88.50,148.90)vs.126.40(93.27,161.93),P<0.05].PON-1 activity was inversely correlated with Gensini score(r value was-0.477,P<0.001).Serum PON-1 activity was significantly lower in severe stenosis group than that in mild stenosis group[U/L:93.95(58.65,124.88)vs.135.40(102.85,171.00),P<0.001].ROC curve analysis showed that when the cutoff value of PON-1 was 116.10 U/L,the AUC was 0.738[95%confidence interval(95%CI)was 0.675-0.802],and the sensitivity and specificity were 72.5%and 65.9%respectively.Conclusion There is a negative correlation between coronary Gensini score and PON-1 activity,and PON-1 has certain application value in screening and diagnosis of severe IHD patients.