The investigation of relationship between intestinal microflora and inflammatory bowel disease

LIANG Li-li

doi:10.3969/j.issn.1674-7151.2016.02.007

Abstract：Objective To investigate the relationship between intestinal microflora and inflammatory bowel disease (IBD). Methods 106 cases IBD patients (observation group) were collected in our hospital from June 2014 to June 2015. All patients were divided into ulcerative colitis group (42 cases) and Crohn's disease group(64 cases) according to pathological type. 106 cases IBD patients were divided into symptom re-lief group(22 cases), mild activity group(34 cases) and moderate-severe activity group(50 cases) according to clinical severity scales. At the same time, 100 cases healthy people (control group) were collected from physical examination in our hospital. The infection rates of Staphylococcus aureus, Clostridium difficile and Salmonella in all people were analyzed. Results The infection rates of Staphylococcus aureus, Clostridium difficile and Salmonella in observation group were all higher than that of control group, and the differences all had statistical significance (Pall<0.05). In observation group, the infecion rates of Staphylococcus aureus, Clostridium difficile and Salmonella in Crohn's disease patients were all higher than that of ulcerative colitis patients, but the differences had no statistical significance(Pall>0.05). The infection rates of three bacteria in moderate-severe activity group were all higher than that of mild activity group and symptom relief group , and the differences all had statistical significance (Pall<0.05). Conclusion Intestinal microflora may be an im-portant factor to inducing IBD. The infection of Staphylococcus aureus, Clostridium difficile and Salmonella are closely related to occurrence and development of IBD.