Clinical value of CEA, AFP, CA199 and CA153 in the diagnosis of lung cancer
YANG Ju-hong
LI Cui-ru
Abstract：Objective To analyze the value of carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), carbohydrate antigen 199(CA199) and CA153 in the diagnosis of lung cancer. Methods 70 cases of patients with lung cancer confirmed by imaging and pathology , 60 cases of patients with lung benign lesions and 65 cases of healthy persons were selected as study subjects in our hospital and which were respectively di-vided into lung cancer group, benign lung group and normal group. The levels of CEA, AFP, CA199 and CA153 were measured by automatic electrochemical luminescence instrument. The positive rates of tumor markers mentioned above were compared among the groups. The sensitivity , specificity and accuracy of differ-ent tumor markers in diagnosis of lung cancer were compared. Results There were statistical significance in the differences of CEA, AFP, CA199 and CA153 levels among three groups (Pall<0.05). The levels of CEA, AFP, CA199 and CA153 in cancer group were all higher than that of benign lung group and normal group, and the differences all had statistical significance (Pall<0.01). The levels of CEA, AFP, CA153 in benign lung group were all higher than that of control group, and the differences all had statistical significance(Pall<0.05). There was no statistical significance in the differences of CEA, AFP, CA199 and CA153 levels among different tissue typing groups(Pall>0.05). There were statistical significance in the differences of positive rates of CEA, AFP, CA199 and CA153 among three groups (Pall=0.000). The positive rates of CEA, AFP, CA199 and CA153 in cancer group were all higher than that of control group and benign lung group , and the differences all had statistical significance(Pall<0.05). There was no statistical significance in the differences of positive rates of all the index between begin lung group and control group (Pall>0.05). The sensitivity and accuracy of 4 tu-mor markers in lung cancer diagnosis were all lower, but specificity were all higher, which were all higher than 95.00%, and combined detection could improve the sensitivity and accuracy. Conclusion CEA, AFP, CA199 and CA153 have certain value in the diagnosis of lung cancer , especially the combined detection of tu-mor markers can effectively improve the accuracy of diagnosis of lung cancer.
Keywords：Lung cancerTumor markerPositive expressionDiagnostic value
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 75-78 )