The clinical significance of RDW in early diabetic nephropathy
ZHANG Juan
ZHOU Lei
WEI Dian-jun
Abstract：Objective To investigate the clinical significance of red cell distribution width (RDW) in early diabetic nephropathy(DN). Methods 220 cases of type 2 diabetes mellitus(DM) patients from October 2013 to December 2014 in our hospital were collected, and were divided into simple DM group (118 cases,) and DM with micro-urine protein group (102 cases) according to the 24-hour urinary albumin measurement results. 50 cases normal healthy people were collected as control group at the same period. The results of RDW , HbA1c and blood biochemical were compared among three groups. The correlation results of RDW with the other index were analyzed. The risk factors of early DN were analyzed by logistic regression analysis. Results There were no statistical significance in the differences of age, sex, high density lipoprotein cholesterol, blood pressure, body mass index, serum creatinine, blood urea nitrogen among three different groups (Pall>0.05). There were statistical significance in the differences of pathogenesis, fasting blood glucose(FBG), high sensi-tive C reactive protein(hs-CRP), total cholesterol, and low-density lipoprotein cholesterol among three groups (Pall<0.05). The levels of total cholesterol, low density lipprotein cholesterol and HbA1c in DM with micro-urine protein group and simple DM group were all higher than that of control group , and the differences all had statistical significance (Pall<0.05). The levels of RDW, hs-CRP and FBG were increased along with the in-creasing of disease severity degree, and there were all had statistical significance between each two groups(Pall<05). There were positive correlation among RDW and hs-CRP, FBG and urinary albumin excretion rate (r=0.61, 0.59, 0.74, Pall<0.05). Logistic regression analysis results showed that RDW was an independent risk factor of early DN. Conclusion RDW is an independent risk factor for early DN, may predict the occurrence of early DN.
Keywords：Diabetes mellitusType 2Red cell distribution widthDiabetic nephropathyLogistic regression
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 67-70 )