The clinical significance of cartilage oligomeric matrix protein detection in patients with knee os-teoarthritis
WANG Ping
YAN Ping
ZHAO Na
Abstract：Objective To explore the clinical value of serum cartilage oligomeric matrix protein (COMP) detection in early diagnosis of knee osteoarthritis (KOA). Methods 41 cases patients with KOA in our hospital from March 2013 to September 2015 were collected as KOA group. 30 cases people with health ex-amination at the same time were collected as control group. The levels of COMP , erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) of all the subjects were detected, and the results were analyzed statisti-cally. Results The levels of COMP and ESR of KOA group were all higher than that of control group , and the differences all had statistical significance (Pall<0.05). The levels of CRP of KOA group were higher than that of control group, but the difference had no statistical significance(P>0.05). The COMP showed positive corre-lation with ESR in patients with KOA (r=0.413,P=0.035), but not with CRP(r=0.359,P=0.054). The sen-sitivity and specificity of COMP in KOA diagnosis were 77%and 85%, respectively. The other diagnosis ability indexes of COMP were all better than that of CRP and ESR. Conclusion COMP level detection can be used in the diagnosis of KOA.
Keywords：OsteoarthritisKneeCartilage oligomeric matrix proteinC reactive proteinErythro-cyte sedimentation rate
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 38-40 )