The analysis of clinical test characteristics and the drug resistant situation of the antibiotic-associated diarrhea caused by Candida albicans
WANG Dong-lei
Abstract：Objective To investigate the clinical test characteristics and the drug resistant situation of the antibiotic-associated diarrhea(AAD) caused by Candida albicans. Methods 102 cases AAD patients were selected in our hospital from April 2014 to July 2015, and all patients were retrospectively analyzed. The feces specimens of all AAD patients for bacterial culture and determination. 51 cases AAD patients with Candida al-bicans as observation group, and the other 51 cases without Candida albicans as control group. The biochemical indicators and drug resistant test results of all AAD patients were analyzed. Results The levels of serum potas-sium, serum sodium and fasting blood glucose in observation group were all higher than that of control group, and albumin levels in observation group was lower than that of control group. The differences all had statistical significance (Pall< 0.05). Drug resistant test showed that drug resistant rates of fluconazole, itraconazole, voriconazole, amphotericin B, flucytosine, penicillin G and levofloxacin in observation group were all lower than that of control group, and the sensitive rates were all higher than that of control group. The drug resistant rates of vancomycin and macrodantin in observation group were all higher than that of control group , and the sensitive rates were all lower than that of control group. Conclusion AAD caused by Candida albicans is more serious than AAD casused by other bacteria. So feces specimens detection and determination early to confirming strain will contribute to guid clinical rational use of antimicrobial drugs , and improve safety of antimicrobial. It has a significance to clinical diagnosis and treatment of AAD caused by Candida albicans.
Keywords：Candida albicansAntibiotic-associated diarrheaSerum potassiumSerum sodiumFasting blood glucoseAlbuminDrug sensitive test
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 32-34,50 )