The analysis of the correlation between Helicobacter pylori infection and homocysteine level in patients with carotid atherosclerosis

ZHANG Qi

doi:10.3969/j.issn.1674-7151.2016.01.008

Abstract：Objective To investigate the correlation between Helicobacter pylori infection and serum homocysteine level of patients with carotid atherosclerosis. Methods 180 cases patients with carotid atherosclerosis were selected in our hospital from March 2012 to June 2013. All patietnts were divided into Hp positive group (90 cases patients with Hp) and Hp negative group (90 cases patients without Hp)according to Hp detection. At the same time, all patients were divided into thickened carotid intima-media group (63 cas-es), stable plaque group(64 cases) and unstable plaque group(53 cases). The level of serum Hcy in 180 cases patients were detected, and the correlation between level of serum Hcy and Hp were analyzed. Results In Hp positive group, the level of serum Hcy and carotid artery medial thickness were all higher than that of the Hp negative group, and the differences had statistical significance(P all<0.05). In thickened carotid intima-media group, stable plaque group and unstable plaque grpup, level of serum Hcy in Hp positive patients were all higher than that of Hp negative patients, and the differences all had statistical significance(Pall<0.05). Corre-lation analysis showed that Hp positive patients with thickened carotid intima-media group , stable plaque and unstable plaque group had positive correlation with level of serum Hcy (Pall<0.05). Conclusion Hp infection will lead to level of serum Hcy rising, and then the intima media thickness of the common carotid artery will be increasing and unstable carotid artery plaque will be arising , eventually leading to carotid atherosclerosis.