Analysis of expression characteristics of CEA, NSE and CYFRA21-1 in lung cancer before and after operation
CHEN Ying-jie
Abstract：Objective To investigate the expression and significance of serum carcinoembryonic anti-gen(CEA), neuron-specific enolase (NSE), cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) in lung cancer before and after operation. Methods 81 patients with lung cancer who underwent elective operation and 31 patients with benign lung diseases in our hospital from December 2012 to December 2014 were selected and were included in the lung cancer group and benign lung disease group, respectively. The levels of CEA, NSE and CYFRA21-1 in lung cancer group before and after operation and those in benign lung disease group were detected by electrochemiluminescence immunoassay. Results The CEA, NSE and CYFRA21-1 levels in lung cancer group before and after operation group were all higher than that of benign lung disease group , and in lung cancer before operation group were all higher than that of after operation group ,and the differences all had statistical significance (Pall<0.05). The CEA, NSE and CYFRA21-1 levels in lung cancer I group all lower than that ofⅡ~Ⅳgroups, and the differences all had statistical significance (Pall<0.05). There were statistical significance in the differences of CEA and NSE levels between each two periods amongⅡ~Ⅳperi-ods. The CEA level and positive rate of adenocarcinoma were all higher than that of small cell carcinoma and squamous-celled carcinoma, and the differences all had statistical significance (Pall<0.05). The NSE level and positive rate of small cell carcinoma were all higher than that of adenocarcinoma and squamous-celled car-cinoma, and the differences all had statistical significance (Pall<0.05). The CYFRA21-1 level and positive rate of squamous-celled carcinoma were all higher than that of adenocarcinoma and small cell carcinoma , and the differences all had statistical significance (Pall<0.05). Conclusion CEA, NSE and CYFRA21-1 have high application value in determinating the type of lung cancer , clinical staging and curative effect evaluation.
Keywords：Lung cancerCarcinoembryonic antigenNeuron-specific enolaseCytokeratin 19 frag-ment antigen 21-1AdenocarcinomaSquamous cell carcinomaSmall cell carcinoma
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 18-21 )