The predictive value of serum CA19-9 level in vascular involvement and lymph node metastasis in pa-tients with pancreatic cancer
LIANG Li-li
Abstract：Objective To explore the predictive value of serum tumor marker carbohydrate antigen 19-9 (CA19-9) level in vascular involvement and lymph node metastasis in patients with pancreatic cancer. Methods 92 patients with pancreatic cancer confirmed by clinical pathology from July 2013 to July 2015 in our hospital were selected as the study objects. Univariate analysis was used to analyze the correlation between CA19-9 levels and clinical pathology in patients with pancreatic cancer. Receiver operating characteristic (ROC) curve analysis was adopted to evaluate the predictive value of CA19-9 in vascular involvement and lymph node metastasis. Results There were 30 cases patients with elevated CA19-9, accounting for 32.61%(30/92). TNM staging of tumor, vascular involvement and lymph node metastasis were related to elevated serum CA19-9 level and positive rate (Pall<0.05), but were all not related to the position (Pall>0.05). The sensitivity, specificity and area under ROC curve of CA19-9 in predicting vascular involvement were 67%, 54%and 0.61. The sensitivity, specificity and area under ROC curve of CA19-9 in predictingand lymph node metastasis were 91%, 95%and 0.78. Conclusion Serum CA19-9 has high predictive ability to lymph node metastasis in patients with pancreatic cancer, but the value in prediction of vascular involvement is ordinary.
Keywords：Pancreatic cancerCarbohydrate antigen 19-9Vascular involvementLymph node metastasisReceiver operating characteristic curve
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )