Clinical significance of hTERC expression in post-menopausal women with cervical erosion

PENG Pai; DUAN Qing; WEI Dian-jun

doi:10.3969/j.issn.1674-7151.2016.01.003

Abstract：Objective To explore the clinical significance and expression of the human telomerase RNA component (hTERC) gene in postmenopausal women with cervical erosion. Methods 60 cases post-menopausal women with cervical erosion by naked eye view from February 2015 to August 2015 in our hospital were collected, and they were divided into mild cervical erosion group (19 cases), moderate erosion group (23 cases), severe erosion group (18 cases). 40 cases patients with no cervical erosion were collected as the con-trol group at the same time. All the subjects were all detected by colposcopy and cervical biopsy. The hTERC gene expression was detected by fluorescence in situ hybridization(FISH) technique. Results All the patients were divided into normal, cervicitis, cervical intraepithelial neoplasia (CIN)Ⅰ, CINⅡ, CINⅢand cervical cancer according to the results of cervical biopsy pathology. The positive rates of CINⅢ and cervical cancer showed a increasing trend along with the severity of disease. There were statistical significance in the differ-ences of positive rate of different pathology degree among all the groups(Pall<0.05). The samples of each cer-vical erosion group and control group all showed hTERC gene expression. There were 56 cases patients showed hTERC gene expression, the positive rate was 56.00%(56/100). The positive rates of control group, mild cer-vical erosion group, moderate erosion group and severe erosion group were 10.00%(4/40), 68.42%(13/19), 91.30%(21/23) and 100.00%(18/18), and the difference had statistical significance (χ2=41.283, P<0.05). There was positive correlation between cervical erosion and hTERC gene expression (r=0.936, P=0.000). The sensitivity and specificity of hTERC gene in cervical erosion diagnosis were 87.03%and 83.33%, respectively. Conclusion Cervical erosion patients with the naked eye diagnosed show diverse histological diagnosis , the higher the degree of erosion, the greater the likelihood of CIN and cervical cancer, and hTERC gene expres-sion levels with an increasing trend there.