Clinical value of detection and combined detection of CYFRA21-1, CA19-9 and CEA in the identifi-cation between benign and malignant pleural effusion
SUN Chun-xia
Abstract：Objective To discuss clinical value of detection and combined detection of cytokeratin fragment antigen 21-1(CYFRA21-1), CA19-9(carbohydrate antigen 19-9) and carcino-embryonic antigen (CEA) in the identification between benign and malignant pleural effusion. Methods 80 cases pleural effu-sion patients were collected in our hospital from October 2013 to October 2015 , which were divided into 30 cases benign pleural effusion patients and 50 cases malignant pleural effusion patients. Levels of CYFRA21-1 , CA19-9 and CEA were detected by electrochemiluminescence immunoassay. And all data were analyzed sta-tistically. Results Levels and positive rates of CYFRA21-1, CA19-9 and CEA in malignant pleural effusion patients were all higher than that of benign pleural effusion patients , and the differences all had statistical sig-nificance (Pall<0.05). The sensitivity, specificity, positive predictive value, negative predictive value and Youden index of combined detection were all higher than that of single detection. Conclusion CYFRA21-1, CA19-9 and CEA can be used as the index to diagnosing malignant pleural effusion. And combined detection has higher diagnosis value in the identification between benign and malignant pleural effusion.
Keywords：Benign and malignant pleural effusionCytokeratin fragment antigen 21-1Carbohydrate antigen 19-9Carcino-embryonic antigenCombined detection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 233-235 )