The clinical value of procalcitonin and high sensitive C-reactive protein and N-terminal brain natri-uretic peptide precursor in chronic heart failure diagnosis

doi:10.3969/j.issn.1674-7151.2015.04.008

Abstract：Objective To evaluate the clinical value of procalcitonin (PCT), high sensitive C-reac-tive protein(hs-CRP) and N-terminal brain natriuretic peptide precursor(NT-proBNP) in chronic heart fail-ure(CHF) diagnosis. Methods 80 cases patients with CHF from January 2015 to June 2015 in our hospital were collected. The patients were divided into different cardiac function group according to NYHA method in-cluding 38 cases gradeⅡ, 30 cases gradeⅢand 12 cases gradeⅣ. 80 cases healthy controls were selected as control group. The serum PCT, hs-CRP and NT-proBNP of all the subjects were detected, and the results were analyzed statistically. Results The levels of PCT, hs-CRP and NT-proBNP in CHF group were all higher than that of control group, and the differences all had statistical significance(t=63.689,22.015,35.600, Pall<0.05). There were statistical significance in the difference of PCT , hs-CRP and NT-proBNP levels among three dif-ferent cardiac function groups (F= 601.284,973.150,4.829, Pall<0.05). The serum PCT, hs-CRP and NT-proBNP levels in CHF patients were all increasing along with the severity of the disease , and there were statisti-cal significance in the difference of PCT, hs-CRP and NT-proBNP levels between each two groups(Pall<0.05). The positive rates of PCT, hs-CRP and NT-proBNP in CHF patients were 85.0%(68/80), 92.5%(74/80) and 93.8%(75/80), and the positive rate of combine detection was 96.3%(77/80). The sensitivity of PCT, hs-CRP and NT-proBNP in diagnosis CHF were 85.0%, 92.5% and 93.8%, respectively. Thespecificity were 65.2%, 73.9%, 78.2% , respectively. The sensitivity, specificity and Youden index of com-bine detection were 96.3%, 82.6%and 0.79. The other diagnosis index of combine detection were all higher than that of index lonely detection. Conclusion The detection of PCT, hs-CRP and NT-proBNP can be used for diagnosis and cardiac function grading , and the combine detection can improve the accuracy of CHF diag-nosis.