Clinical value of combined detection of different tumor markers in patients with primary liver cancer

CHEN Ying-jie

doi:10.3969/j.issn.1674-7151.2015.04.007

Abstract：Objective To investigate the diagnostic value of combined detection of different tumor markers in primary liver cancer. Methods 34 patients with primary liver cancer, 40 patients with hepatic be-nign lesions and 40 normal subjects in our hospital from December 2012 to December 2014 were selected as the research objects. The levels of serum alpha-L-fucosidase (AFU), alpha-fetoprotein (AFP), gamma-glu-tamyl transpeptidase (GGT) and carbohydrate antigen 50 (CA50) in the three groups were compared. The ac-curacy, sensitivity and specificity of 4 kinds of tumor markers in alone and combined detection in diagnosis of primary liver cancer were analyzed. Results There were statistical significance in the differences of AFU , AFP, GGT and CA50 levels among primary liver cancer group, hepatic benign lesions group and the control group (Pall<0.05). The AFU, AFP, GGT and CA50 levels in primary liver cancer group were all higher than that of hepatic benign lesions group and control group , the AFU, AFP, GGT and CA50 levels in hepatic be-nign lesions group were all higher than that of control group, and the differences all had statistical significance (Pall<0.05). The positive rates of single index and combined detection of primary liver cancer group were all higher than that of hepatic benign lesions, and the differences all had statistical significance (Pall<0.05). The positive rate of combined detection of primary liver cancer group was significantly higher than that of single in-dex (Pall<0.05). The area under receiver operating characteristic curve of AFU, AFP, GGT, CA50 and com-bined detection in diagnosing primary liver cancer were 0.867, 0.774, 0.742, 0.704, 0.984. The diagnosis a-bility of combined detection was higher than that of single index , and the sensitivity was 94.12%, specificity was 87.50%, Youden index was 0.82. Conclusion Combined detection of AFU, AFP, GGT and CA50 can improve the accuracy of primary liver cancer diagnosing.