Procalcitonin and C-reactive protein testing for diagnosing respiratory tract infectious diseases in chil-dren
HE Jian-ye
WANG Fang
YUE Lei
Abstract：Objective To explore the diagnostic value of procalcitonin (PCT) and C-reactive protein (CRP) testing for diagnosing respiratory tract infectious diseases in children. Methods 105 cases children in our hospital from February 2014 to April 2015 were enrolled in this study , which including 39 cases children with bacterial infection, 37 cases children with non-bacterial pathogen infection, and 29 healthy children as the controls. The serum PCT, CRP levels of before and after treatment of children with respiratory tract infec-tious diseases and healthy children were all detected. The results were analyzed statistically. Results There were statistical significance in the differences of PCT, CRP levels among bacterial infection group, non-bacte-rial pathogen infection group and control group (H=61.603, 58.959, Pall<0.01). The serum PCT, CRP levels of bacterial infection group were all higher than that of non-bacterial pathogen infection group and control group, the differences all had statistical significance (ZPCT=-5.950,-6.549, ZCRP=-5.674,-6.591,Pall<0.01). The serum PCT, CRP levels of non-bacterial pathogen infection group were all higher than that of control group, and the differences all had statistical significance (ZPCT=-4.002, ZCRP= -3.708, Pall< 0.01). The serum PCT, CRP levels of bacterial infection group before treatment were all higher than that of after treat-ment, and the differences all had statistical significance (ZPCT=-5.415, ZCRP=-5.428, Pall<0.01). The serum PCT, CRP levels of non-bacterial pathogen infection group before treatment were all higher than that of after treatment, and the differences all had statistical significance (ZPCT=-4.565, ZCRP=-5.137, Pall<0.01). There were no statistical significance in the differences of PCT , CRP levels among after treatment of bacterial infec-tion group, non-bacterial pathogen infection group and control group (H=3.026, 1.531, Pall>0.05). There were statistical significance in the differences of PCT, CRP positive rate among bacterial infection group, non-bacterial pathogen infection group and control group (χ2= 56.85,40.78, Pall< 0.05). The positive rates of PCT, CRP in bacterial infection group and non-bacterial pathogen infection group were all higher than that of control group, and the differences all had statistical significance(Pall<0.05). The positive rates of PCT, CRP in bacterial infection group were all higher than that of non-bacterial pathogen infection group , and the differ-ences all had statistical significance (Pall< 0.05). The area under receiver operating characteristic curve of PCT, CRP and combined detection in diagnosing respiratory tract infectious diseases were 0.928, 0.919 and 0.952, respectively. The sensitivity of PCT, CRP and combined detection were 89.7%, 88.2% and 87.2%, specificity were 84.8%, 87.3%and 95.5%, Youden index were 0.745, 0.755 and 0.827, respectively. Con-clusion The serum PCT and CRP detection can be used for diagnosing the children with respiratory tract in-fection. The joined detection method has relatively high clinical value compared with the two indexes testing lonely.
Keywords：ProcalcitoninC-reactive proteinChildrenRespiratory tract infectionCombined de-tectionReceiver operating characteristic curve
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 211-215 )