Multi-drug resistant Acinetobacter baumannii resistant and carry disinfectant-resistant gene research

doi:10.3969/j.issn.1674-7151.2015.04.003

Abstract：Objective To understand the situation of disinfectant-resistant gene and drug resistance of multi-drug resistant Acinetobacter baumannii. Methods 50 strains multi-drug resistant Acinetobacter bau-mannii were collected in two grade third A class hospitals of Shanxi province from January 2014 to February 2015. The sensitivity of antibacterial agents were tested by K-B method. Disinfectant resistant gene qacEΔ1 was detected by polymerase chain reaction. Results 50 strains multi-drug resistant Acinetobacter baumannii were mainly distributed in department of neurosurgeons, ICU and department of respiration, which were 15 strains(30.0%), 10 strains(20.0%), 9 strains(18.0%), respectively. There were 34 strains sputum specimens (68.0%), 2 strains surgical wounds specimens (4.0%), 2 strains blood specimens (4.0%), 5 strains urine specimens (10.0%), 2 strains drainage specimens (4.0%) and 5 strains specimens of bed handrail in depart-ment of neurosurgeons patients (10.0%) in 50 strains multi-drug resistant Acinetobacter baumannii. Drug re-sistance of 50 strains multi-drug resistant Acinetobacter baumannii to ampicillin/sulbactam, levofloxacin, ceftazidime, cefoperazone/sulbactam, imipenem were 96.0%(48/50), 70.0%(35/50), 100.0%(50/50), 100.0%(50/50), 98.0%(49/50), respectively. There were 21 strains multi-drug resistant Acinetobacter bau-mannii with disinfectant-resistant gene qacEΔ1 in 50 strains multi-drug resistant Acinetobacter baumannii, and the positive rate was 42.0%. Conclusion The drug resistant situation of multi-drug resistant Acinetobac-ter baumannii is very serious, and carry disinfectant-resistant gene qacEΔ1. Therefore, it should be strictly regulate use of antimicrobial agents, and take corresponding measures to preventing epidemic outbreak of mul-ti-drug resistant Acinetobacter baumannii in hospital.