Oxidative stress and peripheral blood lymphocyte percentage analysis in HFMD children

doi:10.3969/j.issn.1674-7151.2015.04.002

Abstract：Objective To explore the clinical significance of serum malondialdehyde (MDA), super-oxide dismutase (SOD), oxidized low density lipoprotein (ox-LDL) levels and peripheral blood lymphocyte percentage changes in patients with hand-foot-and-mouth disease (HFMD). Methods 122 cases common (common HFMD group) and 96 cases severe (severe HFMD group) HFMD children and 100 cases healthy children in our hospital from March 2014 to June 2015 were collected. Serum MDA, SOD, ox-LDL levels and peripheral blood lymphocyte percentage were measured, and the results were analyzed statistically. Results There were statistical significance in the differences of MDA, SOD and ox-LDL levels among control group, common and severe HFMD group (Pall<0.05). The MDA and ox-LDL levels showed increasing trend, and SOD showed decrease trend along with pathogenetic condition development. There were statistical significance in the differences of MDA, SOD and ox-LDL levels between each two groups(Pall<0.05). There were statisti-cal significance in the differences of Ts cell, Th cell and NK cell percentage among control group, common and severe HFMD group (Pall<0.01), except B cell. The Ts cell, Th cell and NK cell percentage showed decrease trend along with pathogenetic condition development. There were statistical significance in the differences of Ts cell, Th cell and NK cell percentage between each two groups (Pall<0.05). The correlation coefficient be-tween peripheral blood lymphocyte percentages and serum levels of MDA, SOD, ox-LDL were all higher than 0.700 (Pall<0.05). Conclusion Serum MDA, SOD, ox-LDL levels and peripheral blood lymphocyte per-centage are closely correlated with the progress of HFMD. Serum MDA , SOD and ox-LDL content have a cer-tain correlation with the percentages of peripheral Th cell, Ts cell and NK cells.