Clinical significance of peripheral blood DNT cells and T lymphocyte subgroup detection in patients with lung cancer
HU Xiao-qian
WANG Su-xia
CAO Ming-shan
Abstract：Objective To study the changes of T lymphocyte subsets and double-negative T-cell (DNT) in peripheral blood of patients with lung cancer and its clinical significance. Methods 120 cases patients with lung cancer(lung cancer group) and 80 cases healthy people(control group) were collected in our hospital from July 2013 to July 2014. The cell count of CD3+, CD4+, CD8+and DNT cells in peripheral blood of lung cancer group and control group were measured by FC500 flow cytometry. All data were analyzed statistically. Results The cell count of CD3+, CD4+and CD4+/CD8+in lung cancer group were all lower than those of control group, and the cell count of CD8+was higher than that of control group, the differences all had statistical significance (Pall<0.05). The cell count of DNT in lung cancer group was higher than that of control group, and the difference had statistical significance (P<0.05). Conclusion The cell count of DNT and T lymphocyte subsets in patients with lung cancer are significantly changed , which indicated that there are immune function disorders in patients with lung cancer.
Keywords：Lung cancerDNT cellT lymphocyte subsetsFlow cytometry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 180-181,157 )