The clinical value of NSE and S100βjoint detection in the diagnosis of children with hand-foot-and-mouth disease combine brain injuries

doi:10.3969/j.issn.1674-7151.2015.03.010

Abstract：Objective To study the clinical application value of S100βserum protein and serum neu-ron-specific enolase (NSE) joint detection in the diagnosis of children with hand-foot-and-mouth disease (HFMD) combine brain injuries. Methods 318 cases of children with HFMD from October 2014 to February 2015 in our hospital were collected, and they were divided into mild group (157 cases), severe group (104 cases) and critical illness group (57 cases) according to the clinical manifestations. 100 cases of healthy chil-dren were selected as the control group. The S100βprotein and NSE levels of all the children were detected , and the results were analyzed statistically. Results There were statistical significance in the differences of S100βprotein and NSE levels among HFMD each groups and control group (F=7.91, F=6.37, Pall=0.010). The S100βprotein and NSE levels in HFMD each groups were all higher than that of control group , and the differences all had statistical significance(Pall<0.05). The S100βprotein and NSE levels increased along with the severity of patient's condition, and the differences all had statistical significance between each two HFMD groups (Pall<0.05). The S100βprotein and NSE levels of severe group in post treatment were all lower than that of before treatment, and the differences all had statistical significance (t=12.35, t=9.71, Pall<0.05). There were no statistical significance in the differences of S100βprotein and NSE levels of critical illness group between before and post treatment(t=0.23, t=0.21, Pall>0.05). Conclusion The detection of serum S100βprotein and NSE can be used for the early diagnosis, condition judgment, and the evaluation of treatment effect and prognosis of HFMD combine brain injuries.