The clinical characteristics of Candida parapsilosis bloodstream infection in critically ill patients

SONG Wei; WEI Dian-ju n

doi:10.3969/j.issn.1674-7151.2015.03.005

Abstract：Objective To investigate the clinical characteristic of Candida parapsilosis infection in blood of critically ill patients. Methods 12 cases patients with Candida parapsilosis infection were collected in our hospital from January 2013 to December 2013. Clinical data, laboratory examination and environmental hygienic monitoring situation of all patients were analyzed. All data were analyzed statistically. Results There were 8 cases patients with hyperpyrexia and 4 cases patients with hyperpyrexia combined shivering. In labora-tory examination, there were all had statistical significance in the differences of neutrophil, lymphocyte, monocyte, PLT, globulin, lactate dehydrogenase, bilirubin and creatinine among admission, confirmed to be infected, treatment for 3 d and treatment for 1 w (Pall<0.05). There were all had no statistical significance in the differences of WBC, RBC, Hb, total protein, albumin, glutamate pyruvate transaminase and aspartate aminotransferase among four periods (Pall>0.05). 12 strains Candida parapsilosis were all sensitivity to all kinds of antifungal drugs. After treatment, there were 8 cases recovery in 12 patients, including 5 cases were treated by fluconazole and 2 cases were treated by caspofungin. Environmental hygienic monitoring showed that the yield was 57.14%(52/91) in 91 samples. The detected bacteria was Acinetobacter baumannii, Acineto-bacter junii, Pseudomonas putida, Aeromonas salmonicida and Chryseobacterium indologenes. Conclusion The clinical manifestation of Candida parapsilosis bloodstream infection in critically ill patients is high fever or high fever with shivering, all the Candida parapsilosis which isolated from our hospital are sensitive to the common antifungal drugs. Clinical need focus on the possibility of Candida parapsilosis bloodstream infection in critically ill patients.