Clinical value of serum amylase, trypsinogen-2, IL-10 and PAF combined detection in the diagnosis of post-ERCP pancreatitis
Abstract：Objective To evaluate the expression of serum amylase, trypsinogen-2, interleukin-10 (IL-10) and platelet activating factor (PAF) in post-ERCP pancreatitis (PEP) patients, and their diagnostic value of combined detection in the diagnosis of PEP. Methods 120 cases of ERCP patients were divided into control group(60 cases) and PEP group(60 cases) in our hospital from August 2012 to November 2013. Serum amylase, trypsinogen-2, IL-10 and PAF levels before operation, 4 h after surgery and postoperative 24 h in the two groups were detected by Johnson&johnson Vitros-350 automatic chemical and biochemical analyzer , and the test results were statistically analyzed. Results In patients with PEP, 4 h after surgery and postopera-tive 24 h serum amylase, trypsinogen-2, IL-10 and PAF levels were all higher than those of before operation and 4 h after surgery and postoperative 24 h in control group, and the differences all had statistical significance (Pall<0.05). The highest level of serum amylase in PEP group was postoperative 24 h, and the highest levels of trypsinogen-2, IL-10 and PAF were 4 h after surgery. The sensitivity, specificity and accuracy of combined detection were 95.0%, 91.7% and 85.0%, respectively, which all higher than indicators single detection. Conclusion Serum amylase, trypsinogen-2, IL-10 and PAF levels individual detection has clinical signifi-cance in PEP disease, and the combined detection of serum amylase, trypsinogen-2, IL-10 and PAF levels can improve the early diagnostic value of PEP.
Keywords：Endoscopic retrograde cholangiopancreatographyPost-ERCP pancreatitisSerum amy-laseTrypsinogen-2IL-10Platelet activating factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 90-93 )