Clinical diagnosis value of inflammatory cytokines in patients with primary hepatocellular carcinoma

GAO Hong-yuan

doi:10.3969/j.issn.1674-7151.2015.02.005

Abstract：Objective To investigate the levels of IL-6, IL-1β, IL-10, IL-17, TNF-αand IL-27 in the serum of patients with primary hepatocellular carcinoma , and to explore their relationship with hepato-cellular carcinoma. Methods 100 hepatocellular carcinoma patients were collected from January 2012 to De-cember 2014 in our hospital, which were divided into non-metastasis group (48 cases) and hepatic metastasis group(52 cases). All cytokines were detected by Luminex xMAP technology, and all data were analyzed statis-tically. Results Levels of IL-17 and IL-27 in hepatic metastasis group were all higher than that of non-metastasis group, and the differences all had statistical significance (Pall<0.05). In hepatic metastasis group, only IL-17 and IL-1βhad positive correlation (r=0.275,P=0.048). Receiver operating characteristic curve showed that the area under the curve of IL-17 and IL-27 detection of hepatocellular carcinoma metastasis was 0.664 and 0.818, respectively. And the cutoff value were 2.005 pg/mL and 238.95 pg/mL. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index of IL-17 de-tection of hepatic metastasis were 83.3%, 35.7%, 58.1%, 43.4% and 35.7, respectively. The sensitivity, specificity, PPV, NPV and Youden index of IL-27 detection of hepatic metastasis were 98.5%, 64.3%, 62.1%, 44.4%and 62.8, respectively. Conclusion IL-17 and IL-27 are cytokines which promote occur-rence, development and metastasis of hepatocellular carcinoma. IL-17 and IL-27 can be used as effective pre-dictors of liver cancer metastasis and prognosis. The clinical diagnosis of performance indicators levels of IL-27 in hepatocellular carcinoma are all higher than that of IL-17 , which has better diagnosis value to the early metastasis of hepatocellular carcinoma.