The correlation research of telomere length of the peripheral white blood cells with premature coro-nary artery disease

doi:10.3969/j.issn.1674-7151.2015.02.002

Abstract：Objective To study the correlation of telomere length of the peripheral white blood cells with premature coronary artery disease(PCAD). Methods 30 cases PCAD patients diagnosed by coronary ar-teriongraphy in our hospital were collected. At the same time , 30 cases healthy controls matching in gender and age with PCAD group were collected. PCAD patients were divided into 38~42 age group , 43~50 age group and 51~55 age group according to the age. The peripheral blood of all the subjects were collected , and the telomere length of the peripheral white blood cells were detected by southern blot. The results were analyzed statistically. Results The telomere length in PCAD group was shorter than that of control group , and the difference had statistical significance (t= 2.162,P= 0.039). There was statistical significance in the difference of telomere length among three different PCAD groups (F=4.380,P=0.020). The telomere length in 43~50 age group and 51~55 age group were all longer than that of 38~42 age group , and the differences all had statistical signifi-cance (P=0.030,P=0.020). There was no statistical significance in the difference of telomere length between 43~50 age group and 51~55 age group (P=0.090). Conclusion The telomere length of the peripheral white blood cells in patients with PCAD is obviously shorter than that of the normal controls. The telomere length of the peripheral white blood cells is correlated with PCAD.