The significance of MT, VEGF, CA125, CEA and MMP-9 combine detection in NSCLC diagnosis
DING Rui-min
Abstract：Objective To analysis the significance of peripheral blood metallothionein(MT), vascular endothelial growth factor(VEGF), carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA), and matrix metalloprotein-9 (MMP-9) combine detection in advanced stage non-small-cell lung carcinoma (NSCLC) diagnosis. Methods 80 cases patients with advanced stage NSCLC and 72 cases healthy control people from June 2012 to June 2014 in our hospital were collected. The MT, VEGF, CA125, CEA and MMP-9 serum levels of all subjects were all detected and the results were analyzed statistically. Results The serum levels of MT, VEGF, CA125, CEA and MMP-9 in NSCLC group were all higher than that of control group, and the differences all had statistical significance (Pall< 0.05). The sensitivity and specificity of 5 index combine detection were all higher than that of each index alone detection. Conclusion The detection of MT, VEGF, CA125, CEA and MMP-9 can be used in the diagnosis of advanced stage NSCLC, and combine detection can improve the detection rate of the disease.
Keywords：Advanced non-small cell lung cancerMetallothioneinVascular endothelial growth fac-torCarbohydrate antigen 125Carcinoembryonic antigenMatrix metalloproteinase-9
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 42-43,24 )