Correlation of urinary mindin level with renal function injury degree in patients with diabetic nephropathy

WANG Bao-qun

doi:10.3969/j.issn.1674-7151.2015.01.003

Abstract：Objective To discuss the relationship between urinary mindin level and renal function in-jury degree in patients with diabetic nephropathy. Methods 200 cases of type 2 diabetes patients were select-ed as subjects of study from August 2012 to August 2014. All patients were divided into 3 groups according to the 24 h urinary albumin quantitation level: 87 cases in normal albuminuria group (24 h urinary albumin quantitation level<30 mg), 62 cases in microalbuminuria group (30 mg≤24 h urinary albumin quantitation level<300 mg), and 51 cases in macroalbuminuria group (24 h urinary albumin quantitation level≥300 mg). Basic data like height, weight, blood pressure and laboratorial indicators like urinary mindin, fasting plasma glucose (FPG), 2 h postprandial glucose (2 hPG), hemoglobin A1c (HbA1c), blood urea nitrogen(BUN), serum creatinine (Cr) were detected. Glomerular filtration rate (eGFR) was calculated. All data were analyzed statistically. Results In basic data, all index had no statistical significance except course of disease(P<0.05). The levels of BUN, blood Cr, eGFR and urinary mindin were all had statistical significance in three groups(Pall<0.05). The levels of BUN, blood Cr and urinary mindin were increased as the degree of renal injury exacerbation except eGFR. There were positive correlation among urinary mindin, cause of disease, BUN, blood Cr and 24 h urinary albumin quantitation levels(r=0.462, 0.435, 0.336, 0.631, Pall<0.05). There was negative correlation between urinary mindin and eGFR (r=-0.436,P<0.05). Logistic regression analysis showed that the urinary mindin, cause of disease, FPG, 2 hPG, HbA1c, BUN, blood Cr and eGFR were all risk factor of renal function damage in patients with type 2 diabetes mellitus, and the highest risk coefficient was urinary mindin(OR=2.061, 95%CI was 1.363~3.116). Conclusion Urinary mindin level can reflect the renal function injury degree in DN patients, which has better clinical application value.