T he predictive value of urine protein electrophoresis in early renal damage of patients with diabetes mellitus
WEI Yan-yan
LI Xiao-xia
Abstract：Objective To study the diagnostic value of urine protein sodium dodecyl sulfate agarose gel electrophoresis (SDS-AGE) detection in the early renal damage of patients with diabetes mellitus (DM). Methods 132 cases type 2 diabetes mellitus(T2DM) patients in our hospital were collected and were divided into Pr(-) group 65 cases, Pr(+/-) group 32 cases, Pr(1+) group 16 cases, Pr(2+) group 10 cases, Pr(3+) group 9 cases according to the qualitation results of urine protein. 30 cases healthy people were collected as the control group. The SDS-AGE urine protein electrophoresis, 24 h urine albumin (24 h-Alb) quantitative, serum creatinine (SCr) and blood urea nitrogen (BUN) of all the subjects were detected, and the results were analyzed statistically. Results In 132 cases T2DM patients, there were 15 cases (15/132, 11.4% ) proteinuria negative, 45 cases (45/132, 34.1%) physiologic proteinuria, and 72 cases (72/132, 54.5%) pothological proteinuria which including 29 cases (29/132, 22.0%) miscellaneous proteinuriam, 25 cases (25/132, 18.9%) tubular proteinuria and 18 cases(18/132, 13.6%) glomerular proteinuria. The positive rate of SCr, BUN, 24 h-Alb and SDS-AGE urine protein electrophoresis in 132 cases T2DM patients were 5.3%(7/132), 24.2%(32/132), 41.7%(55/132) and 54.5%(72/132), respectively. The positive rate of SCr, BUN, 24 h-Alb and SDS-AGE urine protein electrophoresis showed a increasing trend along with the urine protein quantity. The positive rate of SDS-AGE urine protein electrophoresis was higher than that of SCr , BUN, 24 h-Alb, and the differences all had statistical significance (Pall<0.05). Conclusion SDS-AGE urine protein electrophoresis can reflect urinary protein components of DM patients intuitively , and judge the position and degree of kidney damage, which has early prediction value for the early renal damage in the patients with DM.
Keywords：Diabetes mellitusRenal damageProteinuria electrophoresisCreatinineBlood urea ni-trogenPrediction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )