Molecular epidemiology survey of abnormal hemoglobin in Shaoguan region of Guangdong Province
Abstract：Objective To investigate the molecular epidemiological characteristics of abnormal hemoglobin (Hb) in Shaoguan, Guangdong Province. Methods A total of 9731 cases local people from November 2011 to May 2012 were subjected to blood cell analysis and Hb electrophoresis screening. Elec-trophoresis abnormal specimens were further gene sequencing. Results 45 cases of abnormal Hb were found. The incidence was 0.46%,including 7 case E zone, 9 cases G/D zone, 7 cases J zone,6 cases K zone,16 cas-es Q zone. Gene sequencing results showed that there were 25 cases α likeglobin mutation and 20 cases βlikeglobin mutation,and the gene frequency were 1.285×10-3 and 1.028×10-3, respectively. 9 kinds of abnor-mal Hb were found including 16 cases of Hb Q-Thailand, 7 cases of HbE, 6 cases of Hb G-Chinese, 6 cases of Hb New York, 3 cases of Hb G-Coushatta, 3 cases of Hb J-Bangkok, 2 cases of Hb J-Broussais, 1 case of Hb Ottawa, 1 case of Hb G-Taipei. Conclusion The incidence of abnormal Hb in Shaoguan is higher than the average of China. The gene type and distribution show a particular Hakka genetic characteristic of gene flow confluence of the south and north of China.
Keywords：Abnormal hemoglobinMolecular epidemiologyGene sequencing
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 179-181 )