Expression and significance of T lymphocyte CD69 in children paitents with epstein-barr virus-asso-ciated hemophagocytic syndrome
BAI Zhi-yao
SONG Jian-xin
Abstract：Objective To explore the change and significance of the peripheral blood T lymphocyte CD69 expression in children patients with epstein-barr virus-associated hemophagocytic syndrome (EBV-AHS). Methods The expression levels of CD3+CD4+CD69+and CD3+CD8+CD69+in EBV-AHS children(28 cases in acute phase and 21 cases in paracmasis) and 30 cases of healthy controls were detected by flow cy-tometry method. The results were analyzed statistically. Results There were statistical significance in the dif-ferences of CD3+CD4+CD69+and CD3+CD8+CD69+expression levels among three groups(Pall<0.01). The ex-pression levels of CD3+CD4+CD69+and CD3+CD8+CD69+in acute phase group were all higher than that of paracmasis group and control group, and the differences all had statistiacal significance (Pall<0.01). The ex-pression levels of CD3+CD4+CD69+and CD3+CD8+CD69+in paracmasis group were all higher than that of con-trol group, and the differences all had statistiacal significance (Pall<0.01). Conclusion Excessively activate of T lymphocyte play an important role in the EBV-AHS attack procession. Detection of T lymphocyte CD69 expression is helpful for treatment effect judgment in clinical , and provide theoretical basis for application of immune modulators.
Keywords：Epstein-barr virus associated hemophagocytic syndromeT lymphocyteCD69Chil-dren
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 173-175 )