The clinical value of early diagnosis by determining C-peptide and kidney related protein in the pa-tients with diabetic nephropathy
XU Yong
JIANG Da-yong
MAO Zhi-hua
Abstract：Objective To explore the clinical value of early diagnosis by determining C-peptide (CP) and kidney related protein in the patients with diabetic nephropathy (DN). Methods 280 cases DN patient and 60 cases healthy people(control group) in our hospital were selected from January 2005 to December 2013. The serum CP,β2-microglobulin(β2-MG) levels and urine CP,β2-MG, albumin(Alb) and immunoglobulin G (IgG) levels were determined by chemiluminescence immune assay and radioimmunoassay, and all data were analyzed statistically. Results In 280 cases DN patient, the levels of serum CP,β2-MG and urineβ2-MG,Alb and IgG were higher than those of control group, and level of urine CP was lower, and the differences all had statistical significance (Pall<0.01). Before treatment, the levels of serum CP,β2-MG, urineβ2-MG, Alb and IgG in 75 cases DN early grade patient, 119 cases DN without ketoacidosis patient and 86 cases DN with ketoacidosis patient were all higher than those of control group, and level of urine CP was lower than that of control group, the differences all had statistical significance (Pall<0.05). After treatment, except levels of serum CP,β2-MG and urine CP,β2-MG, Alb and IgG in 75 cases DN early group patient were return to nor-mal, others were compared with control group, the differences all had statistical significance (Pall< 0.05). Conclusion Levels of CP and kidney related protein can reflect the condition of kidney injury in DN patients , and also have an important value to monitoring clinical treatment.
Keywords：Diabetic nephropathyC-peptideβ2-microglobulinAlbuminImmunoglobulin GKetoacidosisEarly diagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 168-172 )