The expression and significance of urine NGAL in pregnancy hypertensive renal injury diseases

LI Wei-ning; WEI Dian-jun; NING Li

doi:10.3969/j.issn.1674-7151.2014.03.12

Abstract：Objective To investigate the relationship between urinary neutrophil gelatinase-associ-ated lipocalin (NGAL) level and gestational hypertension of renal injury disease progression. Methods 105 cases pregnancy-induced hypertension syndrome patients in our hospital from September 2013 to April 2014 were selected. Which including 30 cases of patients with gestational hypertension , 30 cases of mild preeclamp-sia, 30 cases of severe preeclampsia and 15 cases eclampsia. 40 cases healthy pregnant women as control group at the same time. Urinary and blood samples were colleted when subjects were admitted to hospital within 24 h and 72 h postpartum. Urine NGAL and serum creatinine (Cr) levels were detected, and the relationship with the disease and its severity were analyzed. Results Levels of blood Cr and urinary NGAL in subjects ad-mitted within 24 h were all higher than that of 72 h postpartum , and the differences all had statistical signifi-cance(Pall<0.05). Comparison between each two group, with disease progression, levels of blood Cr and uri-nary NGAL were increased, and the differences all had statistical significance (Pall<0.05), excepted level of blood Cr between gestational hypertension group and mild preeclampsia group. Pearson correlation analysis showed that levels of blood Cr and urinary NGAL in pregnancy-induced hypertension syndrome patients had positive correlation(r=0.916,P=0.000). Conclusion Detect urinary NGAL level can find and diagnose ges-tational hypertension with impaired renal function early, dynamic monitoring of the changes can evaluate either disease progression and treatment of gestational hypertension of renal injury , and have importance significance for guiding clinical decision making, reduce mother son preeclampsia associated serious complications.