Relationship research between HPV L1 protein expression and cervicallesions degree
ZHAO jing
Abstract：Objective To research the relationship between expression of HPV L1 protein and severi-ty of cervical lesions. Methods 529 cases patient were collected in our hospital from February 2013 to August 2013. All patients were detected by liquid-based cytology test and histopathology. HPV L1 protein was detect-ed by immunohistochemistry. All data were analyzed statistically. Results In 529 case patient, the total ac-cordance rate of histopathology was 87.52%(463/529). In liquid-based cytology test, positive rate of HPV L1 protein in 529 case patient was 29.11%(154/529), with in no intraepithelial lesion or malignant lesion, atypi-cal squamous cell of unde-termined significance, low squamous intraepithelial lesion, high squamous intraep-ithelial lesion and squamous cell carcinoma was 20.16%, 36.97%, 65.15%, 18.39%and 0.00%respectively, and the difference among these groups had statistical significance(P<0.05). In histopathology, positive rates of HPV L1 protein in cervical intraepithelial neoplasia (CIN) Ⅰ, CINⅡ, CINⅢ and cervical cancer was 26.16%, 60.76%, 29.33%, 16.54%and 0.00%respectively, and the difference among these groups had sta-tistical significance (P<0.05). HR-HPV DNA detection showed that with HR-HPV DNA capacity increased, level of HPV L1 protein was increasing. There were statistical signicficance among these groups except between 1.1~9.9 pg/mL and 10~100 pg/mL (Pall<0.05). Conclusion Expression of HPV L1 protein decrease with increasing degree of cervical lesions. It has important significance in screening and prevention of precancerous lesions of the expression of HPV L1 protein.
Keywords：Immunocytochemistry methodHPV L1 proteinCervical lesionsHistopathologyLiq-uid-based cytologyHPV DNA
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 157-160 )