Effect of serum 25-hydroxy vitamin D level in diabetic nephropathy

doi:10.3969/j.issn.1674-7151.2014.03.04

Abstract：Objective To explore the relationship between serum 25-hydroxy vitamin D[25-(OH)D] level and kidney injury of type 2 diabetes. Methods 148 cases type 2 diabetes patients and 50 cases healthy people (control group) were collected in our hospital from December 2012 to May 2013. All patients were di-vided into normal proteinuria group [(albumin/creatinine, Alb/Cr)< 30 mg/gCr], microproteinuria group (Alb/Cr 30~299 mg/gCr) and massive proteinuria group(Alb/Cr≥300 mg/gCr). 25-(OH)D, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), uric acid (UA), total cholesterol (TCH), triglyceride (TG), high density lipoprotein(HDL) and low density lipoprotein(LDL) were detected. All data were analyzed statistically. Results Level of proteinuria in type 2 diabetes patients was increased along with the extension of course. There was statistical significance in the difference of pathogenesis among three disease groups (P<0.01). Lev-els of contractive pressure, Alb/Cr, FPG, HbA1c, TCH, TG, LDL, UA and serum Cr in type 2 diabetes pa-tients were all higher than that of control group, and levels of glomerular filtration rate (eGFR) and HDL were all lower than that of control group, the differences all had statistical significance (Pall<0.05). The levels of 25-(OH)D in massive proteinuria group and microproteinuria group were all lower than that of normal protein-uria group and control group, and the differences all had statistical significance (Pall<0.01). Level of 25-(OH)D in>10 years course patients was lower than that of 5-10 years course and<5 years course, and the differences all had statistical significance(Pall<0.05). Pearson relationship analysis showed that level of serum 25-(OH)D had negative correlation with levels of Alb/Cr, serum Cr and UA, but had positive correlation with eGFR(Pall<0.05). Multiple regression analysis showed that level of serum 25-(OH)D was independently cor-related with kidney injury of type 2 diabetes (β=-0.39,P<0.01), the OR was 2.98. Conclusion Serum 25-(OH)D is an independent risk factor to kidney injury of diabetes, which level reducing may lead to diabetic nephropathy.