Evaluate the diagnostic value of prostatic carcinoma diagnosis index by ROC curve

HUANG Mei; XIONG An-ying

doi:10.3969/j.issn.1674-7151.2014.02.008

Abstract：Objective To investigate the diagnostic value of total prostate specific antigen (tPSA), free PSA (fPSA) and fPSA/tPSA in prostatic carcinoma (PCA) diagnosis. Methods 23 cases PCA patients, 246 cases benign prostate hyperplasia (BPH) patients and 85 cases healthy controls in our hospital from Jan-uary 2008 to December 2012 were collected. The levels of tPSA , fPSA and fPSA/tPSA were detected by chemiluminescence analytic method. The diagnosis efficiency of each index in diagnosing PCA were analyzed by receiver operating characteristic(ROC) curve. Results There were statistical significance in the difference of tPSA and fPSA levels among three group(Pall<0.01), except fPSA/tPSA(P>0.05). The levels of tPSA and fPSA in PCA group were all higher than those of BPH group and control group , and the differences all had sta-tistical significance (Pall<0.05). The levels of tPSA and fPSA in BPH group were all higher than those of con-trol group, and the differences all had statistical significance (Pall<0.05). The area under ROC of tPSA, fP-SA, tPSA+fPSA and fPSA/tPSA in diagnosing PCA were 0.995, 0.991, 0.995 and 0.362, respectively. The cutoff value of tPSA and fPSA in diagnosing PCA were 23.09μg/L and 4.05μg/L, and the corresponding sen-sitivity and specificity were 100.0%, 96.1%and 100.0%, 94.3%. Conclusion tPSA and fPSA have better diagnosis efficiency in PCA diagnosing, and their cutoff value were 23.09μg/L and 4.05μg/L, respectively.