The value of antinuclear antibody series in autoimmune diseases diagnosis
Abstract：Objective To evaluate the value of antinuclear antibody(ANA) series tests in the diagno-sis of autoimmune diseases(AID). Methods 513 cases AID patients and 353 cases without AID patients were selected from May 2012 to May 2013. And results of ANA series tests in these patients were analyzed retro-spectively. Results The positive rates of anti-dsDNA antibody, anti-histone antibody, anti-nucleosomes an-tibody, anti-SM antibody, anti-SSA antibody, anti-rRNP antibody in systemic lupus erythematosus (SLE) group were all higher than those of control group , and the differences all had statistical significance (Pall<0.05). The positive rates of anti-U1RNP antibody and anti-SSA antibody in mixed connective tissue disease (MCTD) were all higher than those of control group, and the differences all had statistical significance (Pall<0.05). The positive rates of anti-SSA antibody and anti-SSB antibody in primary Sjogren's syndrome group, and anti-SCL-70 antibody and anti-CENP-B antibody in progressive systemic sclerosis group , and anti-JO-1 antibody in polymyositis and dermatomyositis group were all higher than those of control group , and the differ-ences all had statistical significance(Pall<0.05). The positive rate of anti-histone antibody, anti-nucleosomes antibody, anti-rRNP antibody and anti-dsDNA antibody all together positive in SLE group was higher than that of MCTD group, and the difference had statistical significance (P<0.05). Conclusion ANA series tests have great significance in the discrimination diagnosis and diagnosis of the AID.
Keywords：Autoimmune diseaseAntinuclear antibody seriesDiagnosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 87-90 )