Evaluation of bone turnover markers in rheumatoid arthritis patients with osteoporosis
Abstract：Objective To investigate the incidence of osteoporosis(OP) in rheumatoid arthritis(RA) patients by monitoring total N-terminal propeptide of type I procollagen (TPINP), β-collagen specific se-quences (β-CTx) and N-terminal-midfragment of osteocalcin (N-MID) in serum. Methods Bone mineral density (BMD) of 70 cases of RA inpatients and 60 cases of volunteers were measured by dual-energy X-ray absorptionmetry. The serum TPINP, β-CTx and N-MID were measured by electrochemiluminescence im-munoassay. The incidence of OP, bone turnover markers in RA patients and volunteers, bone turnover markers in the RA patients with or without OP were evaluated. Results The incidence of OP in RA patients group was significantly higher than that of control group, and difference had statistical significance(χ2=11.07, P<0.05). Compared with control group, the levels of TPINP and N-MID in RA patients were obviously decreased, but the level ofβ-CTx was dramatically increased and the differences all had statistical significance (Pall<0.05). There was no statistical significance in the differences for TPINP and N-MID between RA patients with OP and without OP(t=0.69, t=0.58, Pall>0.05), exceptβ-CTx(t=3.09, P<0.05). Conclusion The measurement of the serum TPINP,β-CTx and N-MID levels are helpful for evaluating the incidence of OP in RA patients.
Keywords：Total N-terminal propeptide of type I procollagenβ-collagen specific sequencesN-terminal-midfragment of osteocalcinRheumatoid arthritisOsteoporosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 81-83 )