The expressions and correlations of CXCL12 and CXCR4 in gastrointestinal adenocarcinoma

doi:10.3969/j.issn.1674-7151.2014.02.003

Abstract：Objective To detect the expressions of CXCL12 and its receptor CXCR4 in gastrointesti-nal adenocarcinoma, and to evaluate their roles in carcinogenesis, development, infiltration and metastasis as well as their clinical significance. Methods The expressions of CXCL12 and CXCR4 protein were detected by SP immunohistochemical method in different tissues. The expression condition and there correlation with clini-cal pathology were analyzed statistically. Results The positive expressions of CXCL12 and CXCR4 in gastric adenocarcinoma tissue both were higher than those of the normal gastric mucosa tissue , and the differences all had statistical significance(Pall<0.01). The positive expressions of CXCL12 and CXCR4 were closely correlat-ed with metastasis of lymph node and depth of tumor infiltration in gastric adenocarcinoma group , and the dif-ferences all had statistical significance (Pall<0.05). The expressions of CXCL12 and CXCR4 proteins in the colorectal adenocarcinoma tissue were obviously higher than those of the normal colorectal mucosa tissue , and the differences all had statistical significance (Pall<0.01). The positive expressions of CXCL12 and CXCR4 were closely correlated with depth of tumor infiltration and metastasis of lymph node in colorectal adenocarci-noma group, and the differences all had statistical significance(Pall<0.05). Conclusion CXCL12 and its re-ceptor CXCR4 may play an important role in tumorigenesis progression , infiltration and metastasis of gastroin-testinal carcinoma.