Toxic effect and mechanisms of dibutyl phthalate
JI Hong-rui
DU Xia
SONG Yong-bin
LIU Xin
Abstract：Aiming at the current situation that the environmental pollution has become increasingly serious, the effect of dibutyl phthalate (DBP) on the hepatotoxicity and reproductive toxicity was studied.The key enzymes, sperm viability and sperm abnormality rate were tested, and the pathological changes of liver and testis were observed.The results show that DBP can significantly raise the glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), alkaline phosphatase (AKP) and malonaldehyde (MDA), and remarkably reduce the superoxide dismutase (SOD) and catalase (CAT).It means that DBP can induce the lipid peroxidation of liver for mice and early hepatic injury.BPA can penetrate blood-testis barrier, and interfere the growth and development process of sperms.Therefore, DBP is a genotoxic compound which has latent mutagenic damage to the malesex cells.
Keywords：dibutyl phthalate(DBP)hepatotoxicityreproductive toxicitylipid peroxidation injuryblood-testis barriersperm viabilitysperm abnormality ratepathological change
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 230-235 )