Effects of Simvastatin on Bone Mineral Density and Fracture Healing in Postmenopausal Women with Abnormal Blood Lipid Metabolism

Abstract：Objective To investigate the effects of simvastatin (20 mg/d) on bone mineral density and fracture healing in dyslipidemia diabetes patients with upper extremity fractures.Methods 86 cases of postmenopausal women with diabetes mellitus with abnormal blood lipid metabolism were followed up.According to whether the patients took the lipid-lowering drug simvastatin (20 mg/d), they were divided into the control group and the treatment group.The difference of bone mineral density and fracture healing in the distal tibia of the healthy side in the last 3 months.Results During the hospital, there was no significant difference in bone mineral density of the radius between the treatment group and the control group (P＞0.05).After 3 months of treatment, the treatment group bone density compared with before treatment showed no significant difference (P＞0.05);the control group mean bone density increased, but no significant difference before and after treatment (P＞0.05).After 3 months of treatment, there was no significant difference in bone mineral density (P＞0.05) between the treatment group and the control group.There were no significant differences in the number of fracture healing between the treatment group and the control group.Simvastatin (20 mg/d) does not promote the healing of fracture in postmenopausal diabetes women with hyperlipidemia.Conclusion Simvastatin (20 mg/d) has no effect on bone mineral density in the distal radius and fracture healing in hyperlipidemia postmenopausal diabetes mellitus patients with upper extremity fractures.