The Diagnostic Value of PAF Content and Changes of Platelet Parameters in Osteoarthritis of the Knee

Suo Cangping; Ye Yongjie

Abstract：Objective To observe the changes of PAF content and platelet parameters of patients with knee osteoar-thritis.To investigate theireffects in the treatment of knee osteoarthritis and theirusages as diagnostic and prognostic in-dicators in clinical application.Methods 20 cases of healthy people and 96 cases of patients with knee replacement sur-gery patients were included in this study.The platelet parameters was tested by five classifications of blood cells,the PAF content in serum and articular fluid was tested by enzyme-linked immunosorbent assay.And statistical analysis was performed in all results.Results Compared with the normal group,the MPV,PCT and PDW of knee arthritis group increased slightly.The deference was statistically significant between the two groups(P<0.05).The MPV,PCT and PDW of knee arthritis group decreasedto normal levels after treatment,The deference was not statistically signifi-cant between normal group and post-treatment group (P>0.05),The deference was statistically significant between normal group and knee arthritis group(P<0.05).The deference of PLT as not statistically significant in all groups.The r value of each group was calculate by platelet parameters related analysis.The r value of MPV in each group was 0. 001、0.64、0.001,respectively(P=0.00);the r value of PLT in each group was 0.001,0.52,0.001,respectively (P=0. 00);the r value of PDW in each group was 0.001,0.58,0.001,respectively (P=0.00).The above parameters were sta-tistically significant between knee arthritis group and post-treatment group (P<0.05).The r value of PLT was 0.001, 0.001,0.001,respectively (P=0.00),The difference of it was not statistically significant in all groups.The PAF content inserum of knee arthritis group was 6.7 times as normal group's and the platelet parameters in articular fluid of knee ar-thritis groupand7 times as the normal group's.The deference was statistically significant between the two groups(P<0. 05).The PAF content inserum of post-treatment group was 5.6 times as normal group's and the platelet parameters in articular fluid of post-treatment group was 6.1 times as the normal group's.The deference was not statistically signifi-cant between the two groups(P>0.05).The r value of PAF in serum and articular fluid was calculate by analysis in all groups.Only the knee arthritis group'result was relatedto PAF.The r value was rserum 0.78,rarticulart-fluid 0.82(P=0.00),respectively.The differnecewas statistically significant (P>0.05).Conclusion PAF,MPV,PCT and PDW are related to the knee osteoarthritis and can be used as one of the laboratory diagnostic indicators in clinical diagnosis and prognosis.