Polymorphismsin Analysis of TNF-αGene in the Patients with Spine Tuberculosis

Zhang Yukun; Zhou Gang; Huang Weiming

Abstract：Objective To investigate the association of TNF-αgene polymorphisms at position-238A/G and-308A/G with spine tuberculosis.Methods We randomly selected 58 cases of spinal tuberculosis patients and 50 normal people as control group from January to December in 2015 of Sixth Affiliated Hospital in Xinjiang Medical University.Gene polymorphisms with the-308A/G and-238A/G of TNF alpha were studied.Results There was significant difference in genotype frequencies of region at position-238GG and GA in TNF-αgene between spinal tuberculosis patients and con-trol group,P<0.05.There was no significant difference in allele frequencies of region at position-238G and A between two groups,P>0.05.There was no significant difference in genotype frequencies of region at position-308GG and GA in TNF-αgene between two groups,P>0.05.There was significant difference in allele frequencies of region at position-308G and A between two groups,P<0.05.Conclusion TNF-αgenes involved the development process of spinal tuber-culosis,and gene polymorphism was susceptibility with TB,-308 A allele and-238 GA gene may be involved with the occurrence of spinal tuberculosis.