The Clinical Study of Total Knee Replacement for the Treatment of Anaphase Hemophilic Knee Ar-thropathy

Abstract：Objective To explore the effect of total knee replacement for the treatment of anaphase hemophilic knee arthropathy,and to study the operative characteristics and the coagulation factor replacement therapy perioperatively. Methods 6 patients with anaphase hemophilic knee arthropathy underwent unilateral total knee replacement were fol-lowed from September 2010 to March 2014.All cases were type A hemophilia with gradeⅣ 5 and gradeⅤ 1 according to Amold staging.Those were observed including the process and effect of human coagulation factorⅧ replacement therapy in perioperative,the characteristics of total knee replacement for anaphase hemophilic knee arthropathy and the complications.According to AKS(the American knee society score)the knee score and the function score were compared before operation and after 2 years.Results 6 cases were followed up from 2to 5 years with the average of 3.6.There weren’t any articular hemorrhage and incision dehiscence after early,prosthesis loosening later.The knee score rose from (57.7±5.6)before to (97.0±1.4)2 years after operation.The function score rose from (65.0±6.3)to (92.5±4. 2).Conclusion Total knee replacement is a safe and idea terminal therapy for anaphase hemophilic knee arthropathy under ensuring the activity of coagulation factors although the operation is difficult.