The Efficacy Studies of Different Timing Applications Tranexamic Acid in Total Knee Arthroplasty

Yang Ziquan; Ji Jianjun

Abstract：Objective To research and discuss on the application tranexamic acid the hemostatic effect of total knee arthroplasty in patients with perioperative blood loss of efficacy .Methods Were retrospectively analyzed between De-cember 2013 and June 2015,90 cases in our hospital of patients with unilateral total knee replacement for the first time, according to the use of different timing can be divided into three groups:0.5 h preoperative intravenous application of 33 cases of tranexamic acid in group A,intraoperative suture incision vein tranexamic acid application before the 27 cases of group B,no application of tranexamic acid 30 patients in group C.Comparison of three groups of patients with post-operative flow and hidden blood loss,total blood loss and blood transfusion rate,postoperative day 3 hemoglobin values and the incidence of postoperative lower limb deep vein thrombosis and pulmonary embolism.Results Group A and group B patients postoperative blood loss,blood transfusion rate was lower than that in group C,and compared with group B,the effect of group A is more significant,the difference was statistically significant (P< 0.05).Group A and group B patients postoperative day 3 the amount of hemoglobin was significantly higher in group C,and in group A than group B,the difference was statistically significant (P< 0.05),no postoperative 3 group were lower extremity deep vein thrombosis and pulmonary embolism.Conclusion Tranexamic acid can effectively reduce blood loss in patients with total knee arthroplasty,reduce the blood transfusion requirements,and preoperative 0.5 h dosing intraoperative drug effect is more significant.