The Variation Analysis of Glu,GSP,EGF and TGF-β1 after Acute Traumatic Fractures

Guo Qi; Cai Xianhua

Abstract：Objective To investigate the variation and clinical significance of blood glucose (Glu),glycosylated ser-um protein (GSP),epidermal growth factor (EGF)and transforming growth factor beta 1 (TGF-β1)levels after acute traumatic fractures.Methods 150 cases of patients with acute traumatic fractures in our orthopaedic department were selected from 2010 to 2015,and were retrospectively analyzed.There were 32 cases with diagnosis of diabetes under hy-poglycemic therapy (known group),21 cases diagnosed diabetes after admission (unknown group),and 97 cases frac-ture patients without diabetes (non-diabetes group).At the same time,40 healthy patients were selected as the healthy group.The serum Glu,GSP,EGF,TGF-β1 levels were detected and analyzed before admission and after fracture for 2 weeks.Results The Glu levels of the known group,the unknown group’s and non-diabetes group were significantly higher than that of the healthy group (P<0.05)during admission.The GSP levels of the unknown group was signifi-cantly higher than the known group,the non-diabetes group and the healthy group (P<0.05);The Glu levels of the four groups had no statistical significance after operation for 2 weeks(P>0.05),while the GSP levels of the unknow group was significantly higher than the known group,the non-diabetes group and the healthy group (P<0.05).The EGF,TGFβ1 levels in non-diabetes group were significantly higher than the known group,the unknown group and the healthy group with statistically difference (P<0.05).Conclusion The serum Glu level can be the observation index for traumatic stress of post fracture,and the GSP can identify the reason of high Glu levels in patients.The serum EGF, TGF-β1 levels variation may be associated with fracture healing ability of patients.