The rHuEPO and Iron Therapy in Preopative Anaemic Patients Following Primary Total Hip or Knee Replacement

Abstract：Objective To evaluate the efficacy and safety profile of rHuEPO and iron therapy in preoperative anemia pa-tients following primary total hip(THA)and knee arthroplasty(TKA). Methods Preoperative anemia patients undergone THA and TKA because of end staged hip or knee disease from June 2013 to 2015 were retrospectively involved. And they were divided into treatment group and control group based on whether rHuEPO and iron therapy was adopted. Tranexamic acid was routinely used. The primary outcomes were Hb level and transfusion rate,secondary outcomes were length of hospital stay and complications(such as infection,deep vein thrombosis,allergy and fever). Results A total of 147 preoperative anemia pa-tients(89 THAs and 58 TKAs)were involved. 84 patients were in treatment group,and 63 were in control group. The Hb level before surgery was(115. 20 ± 10. 62)g/ L in treatment group,which was similar in control group(112. 30 ± 12. 62 g/ L,P = 0. 133). The Hb level increased preoperatively by 10 g/ L in treatment group(P ﹤ 0. 001). And the Hb level on postoperative day 1 to 5 in treatment group were higher than control group with significant differences(P ﹤ 0. 001). The mean level of Hb drop on POD 3 was 18 g/ L in treatment group,which was lower than control group(P = 0. 007). All of the patients,only 1 patient re-ceived transfusion,and no episode of infection,DVT or allergy reaction occurred. Conclusion The application of rHu EPO combined with iron therapy can increase the Hb level effectively and safely in anemic patients undergoing THA and TKA.