The Efficacy and Safety of Tranexamic Acid to Reduce Blood Loss of Total Knee Arthroplasty

An Shuai; Le Guoping; Zhang Ming

Abstract：Objective The total knee arthroplasty(TKA)peri-operative application of Tranexamic Acid,clear Tranexamic Acid can reduce perioperative blood loss without increasing postoperative deep vein thrombosis(DVT)and pulmonary embolism (PE). Methods In a prospective,randomly selected primary unilateral TKA patients in experimental group in 30 cases and 30 cases in the control group. Two groups were treated according to the guidelines for anticoagulant therapy,the intraoperative blood loss,postoperative drainage,deep vein thrombosis(DVT),pulmonary embolism(PE)prevalence rate were compared be-tween the two groupsResults In the control group,intraoperative blood loss(58. 3 ± 20. 3)mL,more than the experimental group(54. 5 ± 15. 1)mL,there was no statistically significant difference(P = 0. 668). The control group has postoperative drainage of(370 ± 171. 9)mL,which was more than the experimental group(145. 9 ± 137. 9)mL,the difference was statisti-cally significant(P = 0. 01). The control group had a blood loss of(428. 3 ± 177. 7)mL,which was more than the experimen-tal group(200. 5 ± 136. 4)mL. The difference was statistically significant(P = 0. 01). The experimental group and the control group of blood transfusion and transfusion rate difference was statistically significant(P ﹤ 0. 05). The first day after operation, the experiment group HB decreased compared with the control group. The difference was statistically significant(P = 0. 028). 3、5 days after operation,Hb decrease between the groups had no statistical significance. was no lower extremity deep vein thrombosis,pulmonary embolism and serious bleeding events were not found 14 days,1 month,3 months after operation. Con-clusion Primary unilateral total knee arthroplasty in the peri-operative application of tranexamic acid,can effectively control postoperative blood loss,reduce blood transfusion rate,also does not increase postoperative DVT and PE.